RWD Products & Services
Clinically curated RWD powers our suite of oncology products to drive clarity in research, drug development, and patient care.
Our Data and Services
Data: Focus
Custom fit-for-purpose datasets with client-defined elements for external control arms and other project-based use cases.
Data: Focus
Oncology clinical research studies are becoming more niche with narrowly-defined patient subgroups. Focus consists of deidentified real-world data, sourced from EHRs, that gives you the hard-to-find data you need.
Learn More Data: Vantage
Large curated datasets in specific cancers that are updated quarterly. Used for regulatory needs and to support research across an organization.
Data: Vantage
It’s not feasible or efficient to conduct a clinical trial to answer every research question. Vantage satisfies the growing need for broad datasets that are proactively refreshed across hematologic oncology that give a real-world view of cancer populations.
Learn More Data: Vista
Validate early hypotheses with a comprehensive, automated, real-world dataset that provides patient journeys at scale.
Data: Vista
Vista is an EMR based, multi-indication oncology dataset, curated solely through programmatic and automated techniques.
Learn More Platform: Real-World Analytics
Analytics platform gives insight into treatment patterns and disease outcomes.
Platform: Real-World Analytics
COTA’s analytics platform gives life sciences companies and oncology practices access to the most clinically relevant metrics and reporting.
Learn More Data: Clinicogenomics
Combining comprehensive DNA and RNA profiling with real-world clinical and outcome data enables researchers to create predictive models that will allow for more personalized approaches to treatments and to explore novel variants for drug discovery.
Data: Clinicogenomics
Combining deep clinical oncology real-world data with comprehensive genomics testing data supports more precise, personalized cancer research particularly across early discovery and translational epidemiology functions.
Learn More Services: Real-World Insights
COTA’s team of Research Managers and Data Scientists can provide end-to-end study execution - from protocol development through manuscript publication.
Services: Real-World Insights
Services and deliverables are completely customizable depending on a company’s needs and objectives. Our flexible research offerings include protocol development, statistical analysis, and medical writing to support a variety of research needs.
Learn More Services: Real-World Support
If full research services are not necessary, but partners would like input and/or advisory from COTA throughout their project, COTA offers extra support in a capacity of levels.
Services: Real-World Support
The level of COTA engagements can range from straightforward analyses with partners experienced using COTA data to more complicated studies in the regulatory setting.
Learn More 0
+ Million Cancer lives in our network
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+ Oncologists across our network
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FDA and EMA approvals
Geographic representation of patients accessible through our 50/50 mix of academic and community networks.
Data: Focus
Largest inventory in hematologic oncology diseases with the highest quality and deepest data model
- Standard-level curation includes the most medically relevant data elements
- Regulatory-grade data has been successfully used in FDA and EMA filings
- Supports data pooling if needed
How is Focus used?
- Augment clinical trials with external or hybrid control and comparator arms
- Generate and explore hypotheses
- Characterize the natural history of diseases
- Contextualize data generated in clinical trials
Data: Vantage
A Vantage subscription gives life sciences real-time access to broad, curated datasets that are proactively refreshed with new patients added.
- Largest inventory in hematologic oncology diseases with the highest quality and deepest data model
- Volume for each indication based on disease prevalence within the US
- Standard-level curation is based on the most clinically relevant data elements that can power robust analytics
- Access to COTA’s team of oncology and data science experts is included with Vantage license
How is Vantage used?
- Address regulatory and submission needs
- Streamline clinical trial study design
- Answer research questions
- Test and validate hypotheses in real time
- Support HEOR studies
- Commercial strategy optimization
Data: Vista
Vista is an EMR based, multi-indication oncology dataset, curated solely through programmatic and automated techniques.
- Multi-indication dataset, providing insights into the full spectrum of oncology diseases
- Continuous improvements in data and clinical logic through collaboration with our biopharma development partner
- Leverages structured data and machine learning to extract and standardize patient data
How is Vista used?
- Enhance and refine clinical development strategies
- Uncover unmet epidemiological needs
- Patent pending for clinical trial enrollment and trial feasibility
- Monitor safety and other key post-marketing metrics
- Understand a holistic patient journey, including non-oncology insights
Data: Clinicogenomics
COTA’s Clinicogenomics product enhances our deep clinical data with comprehensive genomic profiling information covering:
- Genomic data from multiple vendors including both large panel and whole exome/whole transcriptome sequencing
- SNVs, indels, copy number alterations, fusions, rearrangements, and gene expression levels
- Reported sequencing results summary
- Raw data outputs: VCF, BAM files
- Genomic signatures:
- Homologous recombination repair (HRR)
- Homologous recombination deficiency (HRD)
- Microsatellite Instability (MSI)
- Tumor Mutational Burden (TMB)
- Other:
- HLA class 1 genotyping
- HLA class 1 and 2 levels of expression
- Cell clonality
- Viral infections (EBV, HPV, TTV)
How is Clinicogenomics used?
Our Clinicogenomics data includes both standard of care and emerging biomarkers. Information on emerging biomarkers can enable:
- Early discovery for clinical development teams
- Creation of predictive models that will allow for more personalized approaches to treatments
- Discovery of novel structural and copy variants to identify new druggable targets and mechanisms of action
Platform: Real-World Analytics
COTA’s full service analytics platform can help life sciences and oncology practices make sense of fragmented and often incomplete healthcare data. Users can easily access clinically relevant metrics and reporting needed to understand treatments and outcomes within their patient population.
- Clinically curated EHR data
- Point and click analytics detail the entire patient journey
- Cohorting mechanism allows comparison of patient groups
- Ability to report on patient outcomes and endpoints
How are Real-World Analytics Applied?
- View clinically similar patient cohorts side-by-side to understand differences in care and outcomes
- Insight into consistency of care across sites to support standardization efforts
- Reveal real world outcomes within your patient population
Services: Real-World Insights
We offer best-in-industry data science and analytics services to help partners achieve their clinical research goals.
- Leadership by elite researchers and data scientists
- Option to deploy dedicated resources who will work on your projects only
- Regulatory experts to support the construction of external or hybrid control arms adhering to latest FDA/EMA guidance on RWD
How are Real-World Insight Services Applied?
- Comparative Effectiveness Studies
- Real-World Treatment Outcomes
- Mechanism of Action/Outcomes
- Support for external controls and comparators from concept to TLFs for your dossier
- Market access
- Research publications
Services: Real-World Support
Not in need of our full-research services? But still wanting help navigating throughout your project? COTA offers the option of three levels of engagement/consulting depending upon your needs.
- COTA support and involvement can range from input on 0 to 3+ data deliverables and 2 to 10+ meetings with COTA Medical Team members
How is Real-World Support Applied?
- Based on the level of engagement chosen:
- Supporting outcomes analysis of COTA data for an experienced partner
- Supporting predictive modeling study or other complex analyses
- Supporting high-complexity study, including analyses to support regulatory submission
